What About the Other Cannabinoids? (CBG, CBC, CBN)
CBD has become a commonly known acronym these days, but there are a variety of other powerful cannabinoids that are often overlooked. Hemp produces some amazing compounds that have a wide variety of effects. If you have ever heard of the "entourage effect" then you know where this is going. The additional cannabinoids that help create the entourage effect are also very helpful individually. Let’s take a look at a few awesome C names that you may not be as familiar with.
Cannabigerol (CBG) is often referred to as the mother molecule. This lesser known cannabinoid is found naturally in hemp at very low levels, often less than 1% of total cannabinoids. The hemp plant produces Cannabigerol in the form of CBG-A which is then broken down by enzymes in the plant into CBD-A, THC-A, or CBC-A. Because of this process, CBG-A is considered the “mother” to well known compounds of the plant. With new technology, CBG is able to be extracted at higher quantities and from young plants bred specifically for CBG.
CBG has been the focus of research lately and has shown promising results. In 2015, a study on CBG showed neuroprotective properties in mice with Huntington's disease. CBG is a powerful vasodilator and is thought to be particularly effective in treatment for glaucoma by reducing intraocular pressure. CBG has also shown great promise in fighting cancer by blocking receptors that signal cancerous tumors to grow and is currently being researched as a potential cure for colon cancer. The antibacterial properties of CBG make it an effective natural agent, especially against MRSA.
Recommendation: In addition to a full spectrum CBD oil, we suggest adding a CBG oil for IBD, Glaucoma, cancer, and to stimulate appetite.
Cannabichromene (CBC) is the last of the major cannabinoids that stem from CBG-A. It has been researched for medicinal purposes since its discovery over 50 years ago. CBC binds with the TRPV1 and TRPA1 receptors which are linked to pain perception. When CBC activates these receptors, the ECS releases natural endocannabinoids, like anandamide, which has been shown to reduce anxiety, fear, and pain. CBC has been shown to block pain and inflammation associated with osteoarthritis. In a recent animal study, CBC was shown to work together with other cannabinoids to create a much more powerful anti-inflammatory effect than just one cannabinoid alone. In a 2013 study, CBC had a positive effect on neural stem progenitor cells. They became more viable in the presence of CBC which shows promise as they differentiate into astroglia cells. These astroglia cells perform a large number of functions including reducing oxidative stress, neurotransmitter direction, defending against inflammation and toxicity, and are currently being researched to counter brain pathologies like Alzheimer’s disease. CBC has also been shown to reduce Acne as an anti-inflammatory and by suppressing excessive lipid production in the sebaceous glands. Along with CBD and THC, CBC has been shown to deliver promising antidepressant properties and is being researched as a possible future treatment.
Recommendation: In addition to a full spectrum CBD oil, we would recommend adding CBC for help with depression, pain, swelling, acne, and cancer.
Cannabinol (CBN) is found predominantly in older plants since THC converts into CBN as it ages. The number one effect of CBN is helping with sleep. CBN alone does not have powerful sedative properties, but when combined with a full spectrum hemp oil that has trace THC levels, CBN boosts the entourage effect to create a natural and mild sedative effect to help those with trouble sleeping. In addition, CBN is high in sedating terpenes that make up the rest of the chemicals that hemp produces. CBN is also a great neuroprotectant. In a 2005 study, rodents with ALS showed significant delay in disease onset. CBN may be helpful for glaucoma as a natural treatment with similar results on intraocular pressure reduction of traditional treatments. As an appetite stimulant, CBN has been shown to offer similar effects increasing appetite as THC without the intoxicating effects.